Hepatology
Signal score, how each part rates
ActionabilityPrevalenceStakesEvidence strengthNovelty
See the full rubric →NCACC maps cross-sample spatial niches and reveals cIgG(+) epithelial rare cells driving liver cancer invasion.
Clinical takeawayNo clinical action yet: mechanistic finding in organoid models. Two candidate compounds (nordihydroguaiaretic acid, gallic aldehyde) were identified by virtual screening and validated in patient-derived organoids but have not been tested in humans.
What it foundNCACC framework identified rare cIgG(+) epithelial cells enriched at tumor-invasive fronts with enhanced proliferative and invasive characteristics, associated with disease progression, sustained by STAT1-dependent JAK-STAT signaling.
ContextIn liver cancer, spatial transcriptomics enables detection of rare low-abundance malignant cell populations previously missed by conventional single-cell analysis. Extends known JAK-STAT involvement in cancer to a specific rare epithelial cell population at the invasive front, opening a potential therapeutic direction, but remains mechanistic.
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Hai C … Ma S · Gut · IF 24.6 · PubMed ↗