← Issue №10/ week of Sep 6, 2026/Colorectal

Longitudinal Data from a Large, Multi-Target Stool DNA Colorectal Cancer Screening Program.

From GI Signals issue №10: what this paper found, what it changes, and where it sits against the current standard of care, reviewed by Simon Mathews, MD.

Colorectal retrospective · n=110,410 · Sep 3, 2026 · Am J Gastro · IF 9.8

Longitudinal Data from a Large, Multi-Target Stool DNA Colorectal Cancer Screening Program.

New evidencecolorectal cancer screeningbiomarkerartificial intelligencehealth services
Clinical takeawayPrioritize colonoscopy follow-up within 6 months after a positive mt-sDNA test to maximize advanced adenoma detection, and address system-level barriers to repeat mt-sDNA testing every 3 years after a negative result, as only 35.3% adhered to repeat testing.
What it foundColonoscopy after positive mt-sDNA had a 30.7% advanced adenoma yield and 1.3% adenocarcinoma yield, exceeding specialty society benchmarks (adenoma detection rate >50%). Longer intervals (>6 months) to colonoscopy were associated with higher advanced adenoma detection (trend P=0.001).
ContextConfirms mt-sDNA as a high-yield screening tool but highlights critical gaps in follow-up (65.1% completion within 12 months) and repeat testing adherence (35.3% within 3 years), which undermine program effectiveness.
Reinforcessuggested applicable standard· US Multi-Society Task Force on Colorectal Cancer (Gupta S, et al.), "Recommendations for Follow-Up After Colonoscopy and Polypectomy: A Consensus Update by the US Multi-Society Task Force on Colorectal Cancer," Gastroenterology, 2020

Decision at stakethe clinical decision to use mt-sDNA as a screening tool for colorectal cancer

No single passage of this standard matched the paper closely enough to quote, so none is shown. The standard is cited above.

Our full summary of this standard

After polyp removal, assign the next colonoscopy surveillance interval using USMSTF 2020 based on polyp number, size, and histology (e.g., 1-2 tubular adenomas <10 mm 7-10 years; 3-4 tubular adenomas <10 mm 3-5 years; 5-10 tubular adenomas <10 mm, any adenoma ≥10 mm, or adenoma with tubulovillous/villous histology or high-grade dysplasia 3 years; >10 adenomas 1 year with polyposis evaluation; and for serrated polyps, 1-2 sessile serrated lesions <10 mm 5-10 years, 3-4 sessile serrated lesions <10 mm or a hyperplastic polyp ≥10 mm 3-5 years, and a sessile serrated lesion ≥10 mm or with dysplasia or a traditional serrated adenoma 3 years), and apply the shortest interval indicated when findings are mixed. Confirm complete resection and adequate prep before applying an interval, and use site-check/tumor-board pathways for piecemeal resection and malignant (T1) polyps. Refer for genetic evaluation when Lynch, FAP/AFAP/MAP, or serrated polyposis syndrome criteria are met.

US Multi-Society Task Force on Colorectal Cancer (Gupta S, et al.), "Recommendations for Follow-Up After Colonoscopy and Polypectomy: A Consensus Update by the US Multi-Society Task Force on Colorectal Cancer," Gastroenterology, 2020 · reviewed 2026-07-23 ↗
Garg SK … Chaudhary R · American Journal of Gastroenterology · IF 9.8 · PubMed ↗Permalink
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