← Issue №10/ week of Sep 6, 2026/Colorectal

New persistent opioid use after colorectal surgery in Sweden: A nationwide register-based cohort study.

From GI Signals issue №10: what this paper found, what it changes, and where it sits against the current standard of care, reviewed by Simon Mathews, MD.

Colorectal retrospective · n=14,233 · Sep 1, 2026 · Colorectal Disease · IF 3.2

New persistent opioid use after colorectal surgery in Sweden: A nationwide register-based cohort study.

New evidenceepidemiologycolorectal surgeryhealth services
Clinical takeawayConsider opioid-sparing strategies, particularly avoiding opioid dispensation within 7 days of surgery, to reduce NPOU risk compared to standard opioid prescribing in opioid-naïve adults undergoing elective colorectal surgery.
What it found2.63% (95% CI, 2.37-2.90%) of opioid-naïve adults developed new persistent opioid use (NPOU) after elective inpatient colorectal surgery, with opioid dispensation within 7 days of surgery (aOR, 2.19; 95% CI, 1.76-2.72) as a modifiable risk factor.
ContextConfirms NPOU as a post-surgical complication in colorectal surgery and identifies modifiable risk factors, aligning with broader efforts to reduce opioid dependence.
Emergingsuggested applicable standard· American Gastroenterological Association, 'AGA Clinical Practice Update on Surgical Risk Assessment and Perioperative Management in Cirrhosis: Expert Review' (Northup PG et al., Clin Gastroenterol Hepatol 2019;17(4):595-606). DOI 10.1016/j.cgh.2018.09.043, PMID 30273751.

Decision at stakeperioperative opioid management in elective colorectal surgery

Defer elective surgery for active GI bleeding, active IBD flare, recent pancreatitis, or unoptimized anemia, and specify perioperative precautions (stress-dose steroids, biologic hold matrix, GLP-1/SGLT2 holds, aspiration precautions) where indicated.

From our summary of this standard, unedited — the part the paper bears on. marks omitted text. Our wording, not the guideline's; read the source for its own text.

Our full summary of this standard

Determine GI surgical clearance based on the specific condition and its activity rather than an automatic sign-off: most stable chronic GI conditions (GERD, IBS, controlled IBD, compensated MASLD, asymptomatic gallstones) may be cleared, while active conditions, cirrhosis, and perioperative drug management require explicit stratification and documentation. For any cirrhotic patient, perform mandatory risk stratification with VOCAL-Penn and Child-Pugh class before clearance; manage variceal prophylaxis per individualized endoscopic and hemodynamic assessment (including NSBB for appropriate candidates) and address rebalanced hemostasis without prophylactic INR correction. Defer elective surgery for active GI bleeding, active IBD flare, recent pancreatitis, or unoptimized anemia, and specify perioperative precautions (stress-dose steroids, biologic hold matrix, GLP-1/SGLT2 holds, aspiration precautions) where indicated.

American Gastroenterological Association, 'AGA Clinical Practice Update on Surgical Risk Assessment and Perioperative Management in Cirrhosis: Expert Review' (Northup PG et al., Clin Gastroenterol Hepatol 2019;17(4):595-606). DOI 10.1016/j.cgh.2018.09.043, PMID 30273751. · reviewed 2026-07-21 ↗
Gedda C … Soop M · Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland · IF 3.2 · PubMed ↗Permalink
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